study of plasma endotholin and nitric oxide in diabetic patients

The endothelin and nitric oxide considered a new system useful to understand and study the molecular mechanisms involved in aging process and in many vascular alteration pathologies. The study of this work was conducted on 65 subjects which divided into three groups. Group I It included 25 NIDDM, 14 male and 11 female. Group II. It included 25 IDDM, 14 male and 11 female. Group III: It included 15 healthy subjects, 8 males and 7 females as control. The following investigation were done to all subjects: fasting and 2 hours PP plasma glucose level-Glycated hemoglobin urine analysis for microalbumin lipid profile plasma levels of endothelin and nitric oxide. The results of this study showed that significant increase in FB and PP blood sugar, cholesterol, triglycerides, LDL, microalbumin and endothelin with significant decreases in nitric oxide levels in both diabetic groups compared to controls. The result of previous parameters did, not differ significantly between both studied diabetic groups. Also these results showed that significant elevation endothelin and significant reduction of nitric oxide in poor controlled diabetic subjects as compared to controlled diabetic subjects. Conclusion plasma endothelin and nitric oxide levels could be added as chemical markers of diabetic control

Effect of age on kidney function in man

The present work was carried out on 20 healthy subjects, they were divided into two groups. Group I consisted of 10 subjects ranging in age from 25 to 35 years. Group II consisted of 10 healthy subjects ranging in age from 70 to 80 years. All subjects were submitted to full general and abdominal examination, urine analysis, ECG, blood sugar were within normal range. Creatinine clearance was performed to all subjects. The results showed that, the mean value of serum creatinine was significantly increased in group II in comparison to group I. There is no significant difference between two groups as regard concentration of creatinine in urine and urine volume per 24 hours. As regard creatinine clearance, the mean value showed that there was highly significant decrease in creatinine clearance in group II as compared to group I. The renal function including GFR as was measured by creatinine clearance deline with advancing age. The decline in GFR in old age is due to morphological changes that take place in the kidney and decline of renal blood flow